PRP vs Cortisone: Which Lasts Longer?

Introduction

Joint pain, tendinitis, and osteoarthritis can limit daily activity and reduce quality of life. Many patients are offered cortisone injections to reduce inflammation and provide short-term relief. While effective for temporary symptom control, cortisone does not address underlying tissue changes.

Platelet-Rich Plasma (PRP) therapy offers a different approach. By using components of your own blood, PRP is intended to support the body’s natural repair processes, rather than just masking discomfort.

This article reviews how PRP and cortisone work, compares the typical duration of relief, and discusses safety and practical considerations.

1. How PRP Works vs. Cortisone

Cortisone: Temporary Inflammation Control

• Cortisone is a synthetic steroid that mimics cortisol, reducing inflammation and pain when injected into joints or tendons.

• Relief is often experienced within 24–72 hours, but usually lasts only a few weeks.

• Repeated injections may carry risks such as tissue weakening, cartilage changes, or tendon stress.

PRP: Supporting the Body’s Natural Repair Processes

• PRP is derived from a small blood sample that is processed to concentrate platelets, which contain growth factors and signaling proteins.

• When injected into affected tissue, PRP is intended to create an environment that may support tissue repair, collagen production, and improved blood flow.

• Onset of improvement may take 1–3 weeks, with effects building gradually over time.

Key distinction: Cortisone primarily reduces inflammation temporarily; PRP is designed to support the body’s natural healing mechanisms.

2. Duration of Relief: What Evidence Shows

• Cortisone: Many patients experience immediate relief, generally lasting 4–8 weeks. Repeated injections may provide diminishing returns.

• PRP: Clinical studies suggest improvement may develop gradually, and some patients report sustained benefits for several months. Individual responses vary based on condition, health status, and severity.

Evidence Snapshot (Peer-Reviewed Studies):

• A 2021 meta-analysis in The American Journal of Sports Medicine found PRP showed longer-lasting improvement in knee osteoarthritis compared to corticosteroids at 6- and 12-month follow-ups.

• PRP has been associated with extended relief in tendinopathies, including lateral epicondylitis, compared to cortisone, though results vary among patients.

Note: Outcomes are patient-specific; PRP may not provide the same level of benefit for everyone.

3. Safety Profile and Cost Considerations

Cortisone

• Pros: Widely available, often covered by insurance, rapid symptom relief

• Considerations: Relief is temporary, repeated use may impact cartilage or tendons, potential systemic effects

PRP

• Pros: Autologous (from your own blood), low risk of allergic reaction, designed to support tissue repair rather than only reduce symptoms

• Considerations: Typically not covered by insurance, requires specialized equipment and training, results are variable and develop over time

Cost Considerations: While PRP may involve higher upfront costs, patients sometimes find that it reduces the need for repeated injections, imaging, or ongoing interventions.

Conclusion: Making an Informed Choice

• Cortisone may be appropriate for short-term symptom management.

• PRP may be considered by patients seeking a regenerative approach to support the body’s natural repair processes.

Individual outcomes vary. A thorough consultation with a qualified provider can help determine which approach aligns with your joint health goals, activity level, and treatment preferences.

Next Step → Schedule Your Discovery Call Now

At Joint Vitality Institute, we provide comprehensive, evidence-informed guidance for active adults experiencing joint pain. Our team can help you:

• Discuss your condition and goals

• Review non-surgical options, including regenerative therapies

• Develop a personalized care plan that addresses your needs

Schedule an Appointment